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KMID : 1130620080040040167
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Journal of Clinical Neurology
2008 Volume.4 No. 4 p.167 ~ p.170
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Steroid-Responsive Recurrent Encephalopathy Associated with Subacute Thyroiditis
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Chung Yun-Jae
Park Kwang-Yeol
Ahn Ji-Hyun
Ha Sam-Yeol
Youn Young-Chul
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Abstract
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Background: Steroid-responsive encephalopathy associated with subacute thyroiditis has, to our knowledge, not been reported previously.
Case Report: A 49-year-old woman was found collapsed and brought to our institution with decreased mentality, dysarthria, and gait disturbance. Brain magnetic resonance imaging and angiography were normal but blood tests revealed thyroid-autoantibody-negative thyrotoxicosis. Results of a 99mtechnetium-pertechnetate scan were compatible with the thyrotoxic phase of subacute thyroiditis. 14-3-3 proteins were detected in cerebrospinal fluid. Her mental status began to improve from the day following steroid administration. Recurrent encephalopathy was found 2 months after the initial admission, which was also effectively treated with steroid.
Conclusions: We speculate that steroid-responsive recurrent encephalopathy associated with subacute thyroiditis is a subtype of Hashimoto’s encephalopathy, and consider that steroid treatment should not be delayed in suspected patients.
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KEYWORD
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brain diseases, 14-3-3 proteins, subacute thyroiditis
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